GENES THAT CONTROL A TEMPERATURE-COMPENSATED ULTRADIAN CLOCK IN CAENORHABDITIS-ELEGANS

被引：70

作者：

IWASAKI, K ^{[1
]}

LIU, DWC ^{[1
]}

THOMAS, JH ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT GENET,SEATTLE,WA 98195

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 22期

关键词：

D O I：

10.1073/pnas.92.22.10317

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Substantial progress has been made in understanding the genetic basis of temperature-compensated circadian clocks. Ultradian rhythms, with a period shorter than 24 h, are at least as widespread as circadian rhythms. We have initiated genetic analysis of defecation behavior, which is controlled by an ultradian clock in Caenorhabditis elegans. The defecation motor program is activated every 45 sec, and this rhythm is temperature compensated. We describe mutations in 12 genes that either shorten or lengthen the cycle period. We find that most of these mutations also disrupt temperature compensation, suggesting that this process is an integral part of the clock. These genes open the way for molecular genetic dissection of this ultradian clock.

引用

页码：10317 / 10321

页数：5

共 29 条

[1] CIRCADIAN CLOCK LOCUS FREQUENCY - PROTEIN ENCODED BY A SINGLE OPEN READING FRAME DEFINES PERIOD LENGTH AND TEMPERATURE COMPENSATION [J].