BIOSYNTHESIS OF ARISTEROMYCIN - EVIDENCE FOR THE INTERMEDIACY OF A 4-BETA-HYDROXYMETHYL-1-ALPHA,2-ALPHA,3-ALPHA-TRIHYDROXYCYCLOPENTANETRIOL

被引：39

作者：

PARRY, RJ ^{[1
]}

HARIDAS, K ^{[1
]}

DEJONG, R ^{[1
]}

JOHNSON, CR ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)97295-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Evidence for the intermediacy of a 4-beta-hydroxymethyl-1-alpha, 2-alpha, 3-alpha-trihydroxycyclopentanetriol (5 or 6) in the biosynthesis of the nucleoside antibiotic aristeromycin (1) has been obtained by administration of doubly-labeled forms of D-glucose to the fermentation broth of Stretptomyces citricolor followed by trapping of the tetrol 5 using isotope dilution methods.

引用

页码：7549 / 7552

页数：4

共 17 条

[1]

BUNDY GL, 1975, TETRAHEDRON LETT, V16, P1957

[2]

FRAZERREID B, 1977, CAN J CHEM, V55, P3986

[3]

FRAZIERREID B, 1977, CAN J CHEM, V55, P3978

[4] ADENOSINE-ANALOGS AS SUBSTRATES AND INHIBITORS OF S-ADENOSYLHOMOCYSTEINE HYDROLASE [J].