EFFECTS OF ENDOTHELIN ON MICROCIRCULATION OF THE PANCREAS

被引：40

作者：

TAKAORI, K ^{[1
]}

INOUE, K ^{[1
]}

KOGIRE, M ^{[1
]}

HIGASHIDE, SI ^{[1
]}

TUN, T ^{[1
]}

AUNG, T ^{[1
]}

DOI, R ^{[1
]}

FUJII, N ^{[1
]}

TOBE, T ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN

来源：

LIFE SCIENCES | 1992年 / 51卷 / 08期

关键词：

D O I：

10.1016/0024-3205(92)90231-D

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Endothelin, a newly described endothelial-derived peptide, has potent vasoconstrictive properties and has been speculated to play a physiological role in the regulation of blood flow in some organs. The present study was designed to evaluate the effects of endothelin-1, endothelin-2 and endothelin-3 on the pancreatic microcirculation. Pancreatic tissue blood flow was measured by a laser Doppler flow meter in anesthetized dogs and endothelin-1, endothelin-2 or endothelin-3 was injected intravenously in graduated doses. Endothelins induced dose-dependent decreases in pancreatic tissue blood flow. Endothelin-1, endothelin-2 and endothelin-3 at a dose of 100 pmol/kg reduced pancreatic blood flow by 45.4%, 19.6% and 51.9%, respectively, whereas systemic arterial blood pressure was not significantly affected. When endothelin-3 was administered at a dose of 1000 pmol/kg, pancreatic blood flow was decreased by 73.5% with a concomitant increase of systemic arterial blood pressure by 17.6%. Endothelins potently decreased pancreatic tissue blood flow, suggesting a possible role of these agents in regulating the pancreatic microcirculation.

引用

页码：615 / 622

页数：8

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