THE EFFECT OF CHOLINERGIC MANIPULATIONS ON THE ANALGESIC RESPONSE TO COBROTOXIN IN MICE

被引：41

作者：

CHEN, R ^{[1
]}

ROBINSON, SE ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PHARMACOL & TOXICOL, RICHMOND, VA 23298 USA

来源：

LIFE SCIENCES | 1990年 / 47卷 / 21期

关键词：

D O I：

10.1016/0024-3205(90)90407-I

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intracerebroventricular (i.c.v.) injection of cobrotoxin (CT), a neurotoxin isolated from the venom of Naja naja atra, produced an antinociceptive response in mice as measured by the tail-flick test. This effect of CT was blocked by systemic administration of atropine, but not by methylatropine or naloxone. Depletion of central acetylcholine (ACh) by hemicholinium-3 (HC-3) blocked the antinociceptive action of cobrotoxin. These results suggest that central cholinergic neurons are important for the mediation of the antinociceptive properties of cobrotoxin. © 1990.

引用

页码：1949 / 1954

页数：6

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