SEPARATION AND SIMULTANEOUS HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF BENZOCAINE AND BENZYL BENZOATE IN A PHARMACEUTICAL PREPARATION

被引：11

作者：

GIGANTE, B

BARROS, AMV

TEIXEIRA, A

MARCELOCURTO, MJ

机构：

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 549卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(00)91432-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple reversed-phase high-performance liquid chromatographic method suitable for the simultaneous determination of benzocaine and benzyl benzoate in dermatological preparations is described. An internal standard method was employed, using a C18 "bonded phase" silica column and a mobile phase consisting of acetonitrile-water (40:60, v/v), with absorption of the column effluent monitored at 254 nm. No sources of interference were observed. The simultaneous determination of both compounds by the method described is rapid and accurate.

引用

页码：217 / 220

页数：4

共 3 条

[1]

BHUZE M, 1984, PHOTODERMATHOLOGY, V1, P277

[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SYSTEMS FOR THE SEPARATION OF LOCAL-ANESTHETIC DRUGS WITH APPLICABILITY TO THE ANALYSIS OF ILLICIT COCAINE SAMPLES [J].