VIRAL CULTURE AND P24 ANTIGENEMIA OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTED INDIVIDUALS CORRELATED WITH ANTIBODY PROFILES DETERMINED WITH RECOMBINANT POLYPEPTIDES OF ALL HIV-1 OPEN-READING FRAMES

被引:23
作者
BAUR, A
VORNHAGEN, R
KORN, K
SONNEBORN, HH
EBERLEIN, B
HARRER, T
BROCKHAUS, W
JAHN, G
机构
[1] UNIV ERLANGEN NURNBERG, INST KLIN & MOLEK VIROL, MED KLIN & POLIKLIN 3, LOSCHGESTR 7, W-8520 ERLANGEN, GERMANY
[2] UNIV ERLANGEN NURNBERG, INST KLIN IMMUNOL & RHEUMATOL, W-8520 ERLANGEN, GERMANY
[3] BIOTEST AG, FORSCHUNGSABT, DREIEICH, GERMANY
[4] STADT KLINIKUM NURNBERG, HAEMOSTASIOL ABT, NURNBERG, GERMANY
关键词
D O I
10.1093/infdis/165.3.419
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The association between viral activity and antibody Profiles was investigated in 202 individuals infected by the human immunodeficiency virus (HIV) grouped according to their Walter Reed clinical stage. Each study group was subdivided into subjects positive or negative for markers of active viral replication: presence of serum p24 antigen and viral culture. In Western blots using recombinant antigens, sera of HIV-positive individuals with positive viral markers had a significantly lower antibody reactivity to several viral proteins than did individuals without viral markers. Noticeably, proteins of the gag (p24, p17) and env (gp120, COOH-terminal part of gp41) open-reading frames revealed a decreased reactivity. The antibody response to the regulatory proteins revealed no or poor association with viral activity in the host. The results suggest that seroreactivity is mainly influenced by factors reflecting the viral activity of an HIV-infected individual, while the clinical stage of the patient is less important. Especially, reductions in antibodies against gp120 and p17 were useful markers associated with increased viral activity.
引用
收藏
页码:419 / 426
页数:8
相关论文
共 45 条
[1]   LONG-TERM EVALUATION OF HIV ANTIGEN AND ANTIBODIES TO P24 AND GP41 IN PATIENTS WITH HEMOPHILIA - POTENTIAL CLINICAL IMPORTANCE [J].
ALLAIN, JP ;
LAURIAN, Y ;
PAUL, DA ;
VERROUST, F ;
LEUTHER, M ;
GAZENGEL, C ;
SENN, D ;
LARRIEU, MJ ;
BOSSER, C .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (18) :1114-1121
[2]   ATG VECTORS FOR REGULATED HIGH-LEVEL EXPRESSION OF CLONED GENES IN ESCHERICHIA-COLI [J].
AMANN, E ;
BROSIUS, J .
GENE, 1985, 40 (2-3) :183-190
[3]   THE NATURAL-HISTORY AND LABORATORY TESTS IN HIV INFECTION [J].
BRUHWILER, J ;
LUTHY, R ;
JOLLERJEMELKA, HI ;
LEDERGERBER, B ;
FIERZ, W ;
SIEGENTHALER, W ;
GROB, PJ .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1989, 114 (26) :1015-1020
[4]   LOCALIZATION OF B-CELL STIMULATORY ACTIVITY OF HIV-1 TO THE CARBOXYL TERMINUS OF GP41 [J].
CHIRMULE, N ;
KALYANARAMAN, VS ;
SAXINGER, C ;
WONGSTAAL, F ;
GHRAYEB, J ;
PAHWA, S .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (03) :299-305
[5]   PLASMA VIREMIA IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
COOMBS, RW ;
COLLIER, AC ;
ALLAIN, JP ;
NIKORA, B ;
LEUTHER, M ;
GJERSET, GF ;
COREY, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) :1626-1631
[6]   VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS IS CORRELATED WITH THE ABSENCE OF HIGH-AFFINITY AVIDITY MATERNAL ANTIBODIES TO THE GP120 PRINCIPAL NEUTRALIZING DOMAIN [J].
DEVASH, Y ;
CALVELLI, TA ;
WOOD, DG ;
REAGAN, KJ ;
RUBINSTEIN, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3445-3449
[7]  
DEWOLF F, 1988, J INFECT DIS, V158, P615, DOI 10.1093/infdis/158.3.615
[8]   EXPRESSION, SECRETION AND PROCESSING OF HIRUDIN IN ESCHERICHIA-COLI USING THE ALKALINE-PHOSPHATASE SIGNAL SEQUENCE [J].
DODT, J ;
SCHMITZ, T ;
SCHAFER, T ;
BERGMANN, C .
FEBS LETTERS, 1986, 202 (02) :373-377
[9]   THE PROGNOSTIC VALUE OF CELLULAR AND SEROLOGIC MARKERS IN INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].
FAHEY, JL ;
TAYLOR, JMG ;
DETELS, R ;
HOFMANN, B ;
MELMED, R ;
NISHANIAN, P ;
GIORGI, JV .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (03) :166-172
[10]   IMMUNOLOGICAL AND SEROLOGICAL MARKERS PREDICTIVE OF PROGRESSION TO AIDS IN A COHORT OF HIV-INFECTED DRUG-USERS [J].
FERNANDEZCRUZ, E ;
DESCO, M ;
MONTES, MG ;
LONGO, N ;
GONZALEZ, B ;
ZABAY, JM .
AIDS, 1990, 4 (10) :987-994