AN IN-VITRO STUDY OF BORONATED PORPHYRINS FOR POTENTIAL USE IN BORON NEUTRON-CAPTURE THERAPY

被引：19

作者：

WOODBURN, K

PHADKE, AS

MORGAN, AR

机构：

[1] Department of Chemistry, University of Toledo, Toledo

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)81006-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of boronated hematoporphyrin analogs differing in Lipophilicity and in the length of the di-ether side chains, and their zinc derivatives were evaluated for use in boron neutron capture therapy. The porphyrins displayed no inherent cytotoxicity towards V79 cells at a concentration of 300 mu M. Cellular uptake varied as a function of lipophilicity and metallation.

引用

页码：2017 / 2022

页数：6

共 17 条

[1]

BARTH RF, 1990, CANCER RES, V50, P1061

[2]

GOMER CJ, 1979, CANCER RES, V39, P146

[3]

HATANAKA H, 1986, BORON NEUTRON CAPTUR

[4] SYNTHESIS OF TETRAKIS-CARBORANE-CARBOXYLATE ESTERS OF 2,4-BIS-(ALPHA,BETA-DIHYDROXYETHYL)-DEUTEROPORPHYRIN-IX [J].