CORRELATION OF LIPOPHILICITY TO BIODISTRIBUTION OF TC-99M-LABELED AMINOTHIOLS

被引：8

作者：

PAPADOPOULOS, M ^{[1
]}

CHIOTELLIS, E ^{[1
]}

VARVARIGOU, A ^{[1
]}

MASTROSTAMATIS, S ^{[1
]}

COTSYFAKIS, C ^{[1
]}

VAVOURAKI, H ^{[1
]}

STATHAKI, S ^{[1
]}

机构：

[1] NCSR DEMOKRITOS,INST RADIOISOTOPES & RADIODIAGNOST,RADIOPHARMACEUT LAB,GR-15310 ATHENS,GREECE

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 01期

关键词：

D O I：

10.1016/0969-8051(93)90142-H

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A series of Tc-99m-DADT complexes substituted with heterocyclic amines were synthesized and tested for their ability to cross the BBB. Each Tc-99m-DADT complex analysed by HPLC was found to consist of two epimers. The more lipophilic epimers were biodistributed in mice. The data demonstrated a significant brain uptake (3-12% dose/g whole brain) and a high lung accumulation (11-85% dose/g) at 2 min p.i. Between the partition coefficients of the technetium complexes, a linear correlation for lung accumulation was observed, while a parabolic curve for brain uptake was found.

引用

页码：101 / 104

页数：4