PYRIDINE CARBOXYLIC-ACIDS AS INHIBITORS AND SUBSTRATES OF THE ESCHERICHIA-COLI GAB PERMEASE ENCODED BY GABP

被引：11

作者：

KING, SC

FLEMING, SR

BRECHTEL, C

机构：

[1] Department of Physiology/Biophysics, University of Texas Medical Branch, Galveston

来源：

JOURNAL OF BACTERIOLOGY | 1995年 / 177卷 / 18期

关键词：

D O I：

10.1128/jb.177.18.5381-5382.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.

引用

页码：5381 / 5382

页数：2

共 8 条

[1]

FRANCO PJ, 1994, J BIOL CHEM, V269, P7379

[2] SELECTIVITY OF THE ESCHERICHIA-COLI OUTER-MEMBRANE PORINS OMPC AND OMPF [J].