SEGMENTAL SCLEROSING GLOMERULAR-LESIONS

Segmental sclerosing glomerular lesions are usually all grouped together and called focal segmental glomerulosclerosis. This has meant that the term that was originally used for a defined clinical entity is now applied to a variety of conditions in man and experimental animals, with the assumption that the morphological changes are the same in all conditions. Studies of the position of segmental lesions within glomeruli, the size of glomeruli and the proportion of glomeruli affected have shown that this assumption is wrong. Such studies have identified a disease that corresponds to the original clinical concept of focal segmental glomerulosclerosis. This begins with the nephrotic syndrome in patients whose renal biopsies show large glomeruli with mesangial hypercellularity and segmental lesions at every tubular origin. Later the biopsies have segmental lesions throughout the glomerular tuft. This disease differs clinically and pathologically from other conditions that have segmental sclerosing lesions, such as in patients with reduced renal mass or patients with hypertension and proteinuria. The term focal segmental glomerulosclerosis is now too ambiguous and unsatisfactory to be used without qualification.