MORPHINE-DEPENDENCE WITH OR WITHOUT TOLERANCE IN FORMALIN-TREATED MICE - FURTHER EVIDENCE FOR THE DISSOCIATION

被引：9

作者：

RAHMAN, AFMM

TAKAHASHI, M

KANETO, H

机构：

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Nagasaki 852, 1-14, Bunkyo-machi

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1994年 / 66卷 / 02期

关键词：

TOLERANCE; DEPENDENCE; MORPHINE;

D O I：

10.1254/jjp.66.277

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge. Dependence also developed in mice rendered tolerant to morphine. Thus, the development of morphine dependence was observed in the absence and presence of tolerance to morphine antinociception; Our results further confirm the dissociation of opioid tolerance and dependence in the animal model of experimental pain/anxiety.

引用

页码：277 / 280

页数：4

共 15 条

[1] DEPENDENCE IN THE ABSENCE OF TOLERANCE TO MORPHINE [J].

JOHNSON, SM ;

DUGGAN, AW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (3-4) :305-308

[2] POSSIBLE DISSOCIATION OF MORPHINE ANALGESIA FROM ITS TOLERANCE LIABILITY IN MICE [J].

KANETO, H ;

HIROTA, N ;

YAMAZAKI, A .

LIFE SCIENCES, 1983, 33 :353-356

[3] EVIDENCE FOR THE DISSOCIATION OF MORPHINE ANALGESIA, TOLERANCE AND DEPENDENCE [J].

KANETO, H ;

YAMAZAKI, A ;

KIHARA, T .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (07) :507-508

[4]

KANNER RM, 1981, ANN NY ACAD SCI, V362, P162

[5]

MELZACK R, 1992, ADV PAIN RES THER, V20, P149

[6] DEVELOPMENT OF PHYSICAL-DEPENDENCE ON MORPHINE NOT ACCOMPANIED WITH TOLERANCE FORMATION [J].

OHTA, A ;

KANETO, H .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1992, 15 (08) :443-447

[7] DISSOCIATION OF TOLERANCE AND DEPENDENCE TO MORPHINE - A POSSIBLE ROLE FOR CHOLECYSTOKININ [J].

PANERAI, AE ;

ROVATI, LC ;

COCCO, E ;

SACERDOTE, P ;

MANTEGAZZA, P .

BRAIN RESEARCH, 1987, 410 (01) :52-60

[8] INVOLVEMENT OF PAIN ASSOCIATED ANXIETY IN THE DEVELOPMENT OF MORPHINE-TOLERANCE IN FORMALIN TREATED MICE [J].

RAHMAN, AFMM ;

TAKAHASHI, M ;

KANETO, H .

JAPANESE JOURNAL OF PHARMACOLOGY, 1994, 65 (04) :313-317

[9] DEVELOPMENT OF TOLERANCE TO MORPHINE ANTINOCICEPTION IN MICE TREATED WITH NOCICEPTIVE STIMULANTS [J].

RAHMAN, AFMM ;

TAKAHASHI, M ;

KANETO, H .

JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 63 (01) :59-64

[10]

RANDALL LO, 1957, ARCH INT PHARMACOD T, V111, P409

← 1 2 →