CONTROL OF SELECTIVITY IN MICELLAR ELECTROKINETIC CHROMATOGRAPHY BY MODIFICATION OF SODIUM DODECYL-SULFATE MICELLES WITH ORGANIC HYDROXY COMPOUNDS

被引:23
作者
KATSUTA, S [1 ]
TSUMURA, T [1 ]
SAITOH, K [1 ]
TERAMAE, N [1 ]
机构
[1] TOHOKU UNIV,FAC SCI,DEPT CHEM,SENDAI,MIYAGI 98077,JAPAN
基金
日本学术振兴会;
关键词
D O I
10.1016/0021-9673(95)00291-T
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Modification of micellar phases with solubilized solutes was examined to control the separation in micellar electrokinetic chromatography (MEKC). The addition of organic hydroxy compounds (1-hexanol, cyclohexanol and phenol) as modifiers to a micellar solution of sodium dodecyl sulfate specifically decreased the capacity factor of some aromatic analytes possessing hydrophilic functional groups. The effect of phenol was different in selectivity to that of 1-hexanol and cyclohexanol. The effects of these modifiers were mainly explained in terms of the saturation of the micellar palisade layer with the modifiers and the hydrogen-bond interaction between the modifier and analyte molecules in the micellar phase. Such micellar modification were applied to improve the MEKC separation.
引用
收藏
页码:319 / 324
页数:6
相关论文
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