IN-VITRO ANTIMALARIAL ACTIVITY OF QUASSINOIDS FROM EURYCOMA-LONGIFOLIA AGAINST MALAYSIAN CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM ISOLATES

被引：70

作者：

ANG, HH ^{[1
]}

CHAN, KL ^{[1
]}

MAK, JW ^{[1
]}

机构：

[1] INST MED RES,DIV FILARIA & MALARIA,KUALA LUMPUR 50588,MALAYSIA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 02期

关键词：

D O I：

10.1055/s-2006-958042

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta,18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 mu M, 0.389-3.498 mu M, and 0.504-2.343 mu M, respectively, compared with 0.323-0.774 mu M for chloroquine.

引用

页码：177 / 178

页数：2

共 10 条

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