TEMPERATURE-DEPENDENCE AND PH-DEPENDENCE OF PROTON RELAXATION RATES IN RAT-LIVER TISSUE

被引：26

作者：

MOSER, E

WINKLMAYR, E

HOLZMULLER, P

KRSSAK, M

机构：

[1] Arbeitsgruppe NMR, Institut für Medizinische Physik, Universität Wien

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 03期

基金：

奥地利科学基金会;

关键词：

PROTON NMR; RELAXATION RATES; PH; RAT LIVER; MODEL DESCRIPTION;

D O I：

10.1016/0730-725X(94)00135-P

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In this study proton NMR relaxation rates R(1) and R(2) and pH of untreated fresh rat liver tissue as well as changes up to 4 h after tissue excision was investigated. Measurements were performed in the temperature range from 7 to 45 degrees C. Dynamic changes in all parameters were observed at higher temperatures (greater than or equal to 30 degrees C). A qualitatively different time course after tissue excision of all three parameters was obtained for 45 degrees C. The relative alterations like the change of relaxation rates referred to a reference value can predict tissue viability. A good correlation between R(2) and pH in the range of 7-37 degrees C was detected and is described by an improved analytical model for R(2) as a function of temperature and pH. The observed data lead to an empirical model given by R(2) (pH,T) = 39.8 + (10.2*Delta pH) + (0.1*Delta T) + (0.2*Delta pH Delta T), where the reference pH value was chosen 7.4 and the reference temperature value 37 degrees C (310.15 K), respectively.

引用

页码：429 / 440

页数：12

共 24 条

[1]

Moser, Holzmuller, Gomiscek, Liver tissue characterisation by in vitro NMR: Tissue handling and biological variation, Magn. Reson. Med., 24, pp. 213-220, (1990)

[2]

Moser, Orr, Podo, Lendinara, Canese, Analysis of the first international data bank on in vitro NMR relaxation times: Animal liver, Magn. Reson. Imaging, 11, pp. 865-872, (1993)

[3]

Holzmuller, Moser, Reckendorfer, Burgmann, Sperlich, Proton spin-lattice relaxation time as liver transplantation graft viability parameter, Magn. Reson. Imaging, 11, pp. 229-239, (1993)

[4]

Holzmuller, Moser, Reckendorfer, Burgmann, Winklmayr, Sperlich, Proton spin-spin relaxation times as liver transplantation graft viability parameter, Magn. Reson. Imaging, 11, pp. 749-759, (1993)

[5]

Moser, Gomiscek, Schuster, Echsel, Systematic investigation of degradation effects on spin-lattice relaxation times in mouse liver by low resolution NMR, Physiol. Chem. Phys. Med. NMR, 21, pp. 73-80, (1989)

[6]

Moser, Gomiscek, Schuster, Echsel, Systematic investigation of degradation effects on spin-spin relaxation times in mouse liver by low-resolution NMR, Physiol. Chem. Phys. Med. NMR, 21, pp. 133-143, (1989)

[7]

Anderson, Kissane, Pathology, 1, (1977)

[8]

Arias, Popper, Schachter, Shafritz, The Liver: Biology and Pathobiology, Hepatocellular Degeneration and Death, pp. 771-784, (1982)

[9]

Slauson, Mechanisms of Disease: A Textbook of Comparative General Physiology, (1982)

[10]

Moser, Gomiscek, Schuster, Holzmuller, Spin-spin relaxation time manifestations of tissue degradation, Croatica Chimica Acta, 65, pp. 211-214, (1992)

← 1 2 3 →