PYOCYANIN FROM PSEUDOMONAS-AERUGINOSA INHIBITS PROSTACYCLIN RELEASE FROM ENDOTHELIAL-CELLS

被引：23

作者：

KAMATH, JM

BRITIGAN, BE

COX, CD

SHASBY, DM

机构：

[1] UNIV IOWA,COLL MED,DEPT MED,IOWA CITY,IA 52242

[2] VET ADM MED CTR,IOWA CITY,IA 52242

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 12期

关键词：

D O I：

10.1128/IAI.63.12.4921-4923.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might alter vascular homeostasis in the absence of cytolysis.

引用

收藏

页码：4921 / 4923

页数：3

相关论文

共 15 条

[1] INTERACTION OF THE PSEUDOMONAS-AERUGINOSA SECRETORY PRODUCTS PYOCYANIN AND PYOCHELIN GENERATES HYDROXYL RADICAL AND CAUSES SYNERGISTIC DAMAGE TO ENDOTHELIAL-CELLS - IMPLICATIONS FOR PSEUDOMONAS-ASSOCIATED TISSUE-INJURY [J].

BRITIGAN, BE ;

ROEDER, TL ;

RASMUSSEN, GT ;

SHASBY, DM ;

MCCORMICK, ML ;

COX, CD .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (06) :2187-2196

[2]

Britigan Bradley E., 1993, P113

[3] ROLE OF PYOCYANIN IN THE ACQUISITION OF IRON FROM TRANSFERRIN [J].

COX, CD .

INFECTION AND IMMUNITY, 1986, 52 (01) :263-270

[4] MODIFICATION OF POSTISCHEMIC INCREASE OF LEUKOCYTE ADHESION AND VASCULAR-PERMEABILITY IN THE HAMSTER BY ILOPROST [J].

ERLANSSON, M ;

BERGQVIST, D ;

PERSSON, NH ;

SVENSJO, E .

PROSTAGLANDINS, 1991, 41 (02) :157-168

[5]

FETZER AE, 1967, AM REV RESPIR DIS, V96, P1121

[6] REDUCED PROSTACYCLIN FORMATION AFTER REOXYGENATION OF ANOXIC ENDOTHELIUM [J].

HEMPEL, SL ;

HAYCRAFT, DL ;

HOAK, JC ;

SPECTOR, AA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (05) :C738-C745

[7] MECHANISMS OF ACTION OF PSEUDOMONAS-AERUGINOSA PYOCYANIN ON HUMAN CILIARY BEAT IN-VITRO [J].

KANTHAKUMAR, K ;

TAYLOR, G ;

TSANG, KWT ;

CUNDELL, DR ;

RUTMAN, A ;

SMITH, S ;

JEFFERY, PK ;

COLE, PJ ;

WILSON, R .

INFECTION AND IMMUNITY, 1993, 61 (07) :2848-2853

[8] NITRIC-OXIDE - AN ENDOGENOUS MODULATOR OF LEUKOCYTE ADHESION [J].

KUBES, P ;

SUZUKI, M ;

GRANGER, DN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4651-4655

[9] CULTURED ENDOTHELIAL-CELLS SYNTHESIZE BOTH PLATELET-ACTIVATING FACTOR AND PROSTACYCLIN IN RESPONSE TO HISTAMINE, BRADYKININ, AND ADENOSINE-TRIPHOSPHATE [J].

MCINTYRE, TM ;

ZIMMERMAN, GA ;

SATOH, K ;

PRESCOTT, SM .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (01) :271-280

[10] INHIBITION OF PLATELET EICOSANOID METABOLISM BY THE BACTERIAL PHENAZINE DERIVATIVE PYOCYANIN [J].

MULLER, M ;

SZTELMA, K ;

SORRELL, TC .

CELLULAR GENERATION, TRANSPORT, AND EFFECTS OF EICOSANOIDS: BIOLOGICAL ROLES AND PHARMACOLOGICAL INTERVENTION, 1994, 744 :320-322