ETHANOL INTAKE AND 3H-SEROTONIN UPTAKE .1. A STUDY IN FAWN-HOODED RATS

被引：28

作者：

DAOUST, M

COMPAGNON, P

LEGRAND, E

BOUCLY, P

机构：

[1] Pharmacochimie - U.F.R. de Medecine et Pharmacie -

来源：

LIFE SCIENCES | 1991年 / 48卷 / 20期

关键词：

D O I：

10.1016/0024-3205(91)90230-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ethanol intake and synaptosomal 3H-serotonin uptake were studied in male Fawn-Hooded and Sprague-Dawley rats. Fawn-Hooded rats consumed more alcohol and more water than Sprague-Dawley rats. Plasma alcohol levels of Sprague-Dawley rats were not detectable but were about 5 mg/dl in Fawn-Hooded rats. Ethanol intake increased the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex, but not in thalamus. In Fawn-Hooded rats, serotonin uptake (Vmax) was higher than in Sprague -Dawley rats cortex. Ethanol intake reduced the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex. In cortex, the carrier affinity for serotonin was increased in alcoholised Fawn-Hooded rats. These results indicate that synaptosomal 3H-serotonin uptake is affected by ethanol intake. In Fawn-Hooded rats, high ethanol consumption is associated with high serotonin uptake. In rats presenting high serotonin uptake, alcoholisation reduces 3H-serotonin internalisation in synaptosomes, indicating a specific sensitivity to alcohol intake of serotonin uptake system.

引用

页码：1969 / 1976

页数：8

共 31 条

[1] SEROTONIN UPTAKE AND IMIPRAMINE BINDING IN BLOOD-PLATELETS AND BRAIN OF FAWN-HOODED AND SPRAGUE DAWLEY RATS [J].