REVIEW OF SELENITE CATARACT

被引：107

作者：

SHEARER, TR

DAVID, LL

ANDERSON, RS

AZUMA, M

机构：

[1] OREGON HLTH SCI UNIV, SCH DENT, DEPT ORAL BIOCHEM & MOLEC BIOL, PORTLAND, OR 97201 USA

[2] OREGON HLTH SCI UNIV, SCH DENT, DEPT BIOCHEM & MOLEC BIOL, PORTLAND, OR 97201 USA

[3] OREGON HLTH SCI UNIV, SCH COMP SCI, DEPT OPHTHALMOL, PORTLAND, OR 97201 USA

[4] OREGON HLTH SCI UNIV, SCH MED, PORTLAND, OR 97201 USA

[5] SENJU PHARMACEUT CO LTD, OSAKA, JAPAN

来源：

CURRENT EYE RESEARCH | 1992年 / 11卷 / 04期

关键词：

D O I：

10.3109/02713689209001789

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed beta-crystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.

引用

页码：357 / 369

页数：13

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