INCREASED CONCENTRATION OF ENDOTHELIN MESSENGER-RNA IN THE MESENTERIC-ARTERIES OF CYCLOSPORINE-INDUCED HYPERTENSIVE RATS

被引：23

作者：

TAKEDA, Y

MIYAMORI, I

YONEDA, T

TAKEDA, R

机构：

[1] Department of Internal Medicine, Kanazawa University, Kanazawa

[2] Department of Internal Medicine, School of Medicine, Kanazawa niversity, Kanazawa 920, 13-1, Takara-machi

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 05期

关键词：

ENDOTHELIN-1; MESSENGER RNA; CYCLOSPORINE; HYPERTENSION; WISTAR RAT;

D O I：

10.1093/ajh/6.5.427

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The aim of this study was to investigate the expression of endothelin-1 (ET-1) in the mesenteric arteries of cyclosporine-induced hypertensive rats. The concentration of plasma ET-1 and of mesenteric artery ET-1 messenger RNA was measured in cyclosporine-induced hypertensive and control rats. The concentration of ET-1 messenger RNA in the mesenteric arteries of cyclosporine-treated rats (25 mg/kg/day for 6 weeks) was significantly greater than in control rats (P < .05). We propose that cyclosporine-induced hypertension may be due to an increased synthesis of ET-1 in the resistant vessels.

引用

页码：427 / 430

页数：4

共 18 条

[1]

Yanagisawa M., Kurihara H., Kimura S., Et al., A novel potent vasoconstrictor peptide produced by vascular endothelial cell, Nature, 332, pp. 411-415, (1988)

[2]

Schini V.B., Hendrickson H., Heublein D.M., Et al., Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cell, Eur J Pharmacol, 20, pp. 333-336, (1989)

[3]

Kon V., Sugiura M., Inagami T., Et al., Role of endothelin in cyclosporine-induced glomerular dysfunction, Kidney Int, 37, pp. 1487-1491, (1990)

[4]

Yokokawa K., Tahara H., Kohno M., Hypertension associated withendothelinsecreting malignant hemangioendothelioma, Ann Intern Med, 114, (1991)

[5]

Benett W.N., Porter G.A., Cyclosporine-associated hypertension, Am J Med, 85, pp. 131-133, (1988)

[6]

Schachter M., Cyclosporine A and hypertension, J Hy- Pertens, 6, pp. 511-516, (1988)

[7]

Takeda Y., Miyamori I., Yoneda I.T., Et al., Endothelin-1 release from the mesenteric arteries of cyclosporine- treated rats, Eurj Pharmacol, 213, pp. 445-447, (1992)

[8]

Miyamori I., Takeda Y., Yoneda T., Et al., Interleukin-2 enhances the release of endothelin-1 from the rat mesenteric artery, Life Sci, 49, pp. 1295-1300, (1991)

[9]

Takeda Y., Miyamori I., Yoneda T., Et al., Production of endothelin-1 from the mesenteric arteries of streptozo- tocin-induced diabetic rats, Life Sci, 48, (1991)

[10]

Takeda R., Morimoto S., Uchida K., Et al., Changes in plasma renin activity and plasma aldosterone in the induced paralytic attack of thyrotoxic periodic paralysis, Acta Endocrinol (Copenhagen), 82, pp. 715-727, (1976)

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