HUMAN INSULIN-LIKE GROWTH-FACTOR TYPE-I AND TYPE-II RECEPTORS ARE NOT IMPRINTED

被引：83

作者：

OGAWA, O ^{[1
]}

MCNOE, LA ^{[1
]}

ECCLES, MR ^{[1
]}

MORISON, IM ^{[1
]}

REEVE, AE ^{[1
]}

机构：

[1] UNIV OTAGO, DEPT BIOCHEM, CANC GENET LAB, DUNEDIN, NEW ZEALAND

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 12期

关键词：

D O I：

10.1093/hmg/2.12.2163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have shown that the insulin-like growth factor type I and II receptors are expressed equally from the maternal and paternal alleles in human tissues. The imprinting status of the type I insulin-like growth factor receptor has not been reported while the type II receptor has previously been shown to be maternally expressed in the mouse. That the imprinting of the insulin-like growth factor type II receptor is not conserved between mouse and humans suggests that the physiological role of the IGF2 receptor may differ between these two species.

引用

页码：2163 / 2165

页数：3

共 17 条

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