DIRECTED MOLECULAR EVOLUTION

被引：79

作者：

JOYCE, GF ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA USA

来源：

SCIENTIFIC AMERICAN | 1992年 / 267卷 / 06期

关键词：

D O I：

10.1038/scientificamerican1292-90

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When a horticulturist wants a redder rose and a cat fancier desires a fluffier Persian, they choose stocks that exemplify those traits and breed the progeny selectively. Similarly, techniques for amplifying, mutating and selecting the most promising macromolecules from large populations are enabling biochemists to imitate nature and direct the evolution of new drugs and catalysts.

引用

页码：90 / 97

页数：8

共 5 条

[1] DIRECTED EVOLUTION OF AN RNA ENZYME
BEAUDRY, AA
JOYCE, GF
[J]. SCIENCE, 1992, 257 (5070) : 635 - 641
[2] SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN
BOCK, LC
GRIFFIN, LC
LATHAM, JA
VERMAAS, EH
TOOLE, JJ
[J]. NATURE, 1992, 355 (6360) : 564 - 566
[3] AN EXTRACELLULAR DARWINIAN EXPERIMENT WITH A SELF-DUPLICATING NUCLEIC ACID MOLECULE
MILLS, DR
PETERSON, RL
SPIEGELMAN, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 58 (01) : 217 - +
[4] INVITRO GENETICS
SZOSTAK, JW
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (03) : 89 - 93
[5] SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT - RNA LIGANDS TO BACTERIOPHAGE-T4 DNA-POLYMERASE
TUERK, C
GOLD, L
[J]. SCIENCE, 1990, 249 (4968) : 505 - 510

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