INTRACELLULAR AND EXTRACELLULAR TRANSPORT OF PERFLUORO CARBON EMULSION FROM SUBCUTANEOUS TISSUE TO REGIONAL LYMPHATICS

被引:7
作者
IKOMI, F [1 ]
HANNA, G [1 ]
SCHMIDSCHONBEIN, GW [1 ]
机构
[1] ALLIANCE PHARMACEUT CORP, SAN DIEGO, CA 92121 USA
来源
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 1994年 / 22卷 / 04期
关键词
D O I
10.3109/10731199409138848
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The aim of this study was to examine the transport mechanism of colloidal particles from subcutaneous tissue to lymphatics. The mechanism of lymph transport was studied in leg prenodal lymphatics of anesthetized rabbits using Imagent(R)LN (60%W/V perfluorooctyl bromide [PFOB] emulsion). Extracellular (dispersed particles) and intracellular (phagocytosed particles by macrophages) PFOB transport was measured in lymph fluid after 0.1 ml injectipn of fluorescently labeled PFOB emulsion into the dorsal skin of the rabbits foot. Samples were collected from cannulated lower leg prenodal lymphatics. Particles of PFOB emulsion were observed by using a fluorescent technique. The foot/leg were moved passively in a rotary direction at 0.3 Hz. Extracellular and intracellular PFOB could be determined in the lymph samples. These findings indicate that both intracellular and extracellular transport mechanisms play a role in the uptake of colloidal particles from interstitial tissue to lymphatics.
引用
收藏
页码:1441 / 1447
页数:7
相关论文
共 20 条
[2]   ENDOTHELIAL PERMEABILITY - PASSAGE OF PARTICLES INTO + OUT OF DIAPHRAGMATIC LYMPHATICS [J].
CASLEYSMITH, JR .
QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1964, 49 (04) :365-+
[3]  
CASLEYSMITH JR, 1968, J ANAT, V103, P202
[4]  
CASTENHOLZ A, 1984, SCAN ELECTRON MICROS, P1343
[5]   THE ROLE OF MACROPHAGES IN PARTICLE TRANSLOCATION FROM LUNGS TO LYMPH-NODES [J].
HARMSEN, AG ;
MUGGENBURG, BA ;
SNIPES, MB ;
BICE, DE .
SCIENCE, 1985, 230 (4731) :1277-1280
[6]   FINE STRUCTURE OF LYMPHATIC CAPILLARY AND ADJOINING CONNECTIVE TISSUE AREA [J].
LEAK, LV ;
BURKE, JF .
AMERICAN JOURNAL OF ANATOMY, 1966, 118 (03) :785-+
[7]  
LOCKANDERSEN J, 1989, CANCER, V63, P77, DOI 10.1002/1097-0142(19890101)63:1<77::AID-CNCR2820630113>3.0.CO
[8]  
2-2
[9]  
LONG DM, 1978, SURGERY, V84, P104
[10]   PERFLUOROCTYLBROMIDE - A RETICULOENDOTHELIAL-SPECIFIC AND TUMOR-IMAGING AGENT FOR COMPUTED-TOMOGRAPHY [J].
MATTREY, RF ;
LONG, DM ;
MULTER, F ;
MITTEN, R ;
HIGGINS, CB .
RADIOLOGY, 1982, 145 (03) :755-758