SUMATRIPTAN BLOCKS NEUROGENIC INFLAMMATION IN THE PERIPHERAL-NERVE TRUNK

被引：19

作者：

ZOCHODNE, DW ^{[1
]}

HO, LT ^{[1
]}

机构：

[1] UNIV CALGARY,NEUROSCI RES GRP,CALGARY,AB,CANADA

来源：

NEUROLOGY | 1994年 / 44卷 / 01期

关键词：

D O I：

10.1212/WNL.44.1.161

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We tested the action of intraperitoneal sumatriptan, a 5-HT1D receptor agonist that aborts migraine headaches, using a model of neurogenic inflammation induced by capsaicin applied to the rat sciatic epineurium. Sumatriptan prevented the development of capsaicin-induced hyperemia without inducing pretreatment vasoconstriction or altering AV shunt flow. The findings indicate that sumatriptan prevents ''neurogenic'' vasodilation by a mechanism other than vasoconstriction or changes in AV shunt flow.

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页码：161 / 163

页数：3

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