EFFECTS OF STILBENES ISOLATED FROM MEDICINAL-PLANTS ON ARACHIDONATE METABOLISM AND DEGRANULATION IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES

被引：83

作者：

KIMURA, Y ^{[1
]}

OKUDA, H ^{[1
]}

KUBO, M ^{[1
]}

机构：

[1] KINKI UNIV, FAC PHARMACEUT SCI, OSAKA 577, JAPAN

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 45卷 / 02期

关键词：

LEUKOTRIENES; LIPOXYGENASE; STILBENE; LYSOSOMAL ENZYME; MEDICINAL PLANT; HUMAN POLYMORPHONUCLEAR LEUKOCYTE;

D O I：

10.1016/0378-8741(94)01206-F

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Studies were made on the effects of stilbene derivatives isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes (PMN-L). Resveratrol (3,4',5-trihydroxystilbene) isolated from the roots of Reynoutria japonica was found to inhibit the 5-lipoxygenase products 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE), 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid (5,12-diHETE) and leukotriene C-4(LTC(4)); its concentrations for 50% inhibition (IC50) were 8.90 x 10(-6) M, 6.70 x 10(-6) M and 1.37 x 10(-6) M, respectively. The IC50 of 5-HETE, 5,12-diHETE and LTC(4) formations of synthetic 3,3',4-trihydroxystilbene were 5.90 x 10(-6) M, 6.30 x 10(-7) M and 8.80 x 10(-7) M, respectively. Moreover, they inhibited the release of lysosomal enzyme such as lysozyme and P-glucuronidase induced by calcium ionophore A 23187 from human PMN-L at 10(-3)-10(-4) M.

引用

页码：131 / 139

页数：9

共 27 条

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