MOLECULAR-CLONING AND SEQUENCING OF HUMAN PALMITOYL-COA LIGASE AND ITS TISSUE-SPECIFIC EXPRESSION

被引：23

作者：

GHOSH, B ^{[1
]}

BARBOSA, E ^{[1
]}

SINGH, I ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,DEPT PEDIAT,CHARLESTON,SC 29425

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1995年 / 151卷 / 01期

关键词：

D O I：

10.1007/BF01076899

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A complimentary DNA clone encoding the entire human palmitoyl-CoA ligase has been isolated from a liver cDNA library and sequenced in it's entirety. The predicted product is a 699 amino acid protein. Southern analysis utilizing the human palmitoyl-CoA ligase gene as a probe revealed varying degrees of similarity amongst various mammalian species. The palmitoyl-CoA ligase gene is highly expressed in liver, heart, skeletal muscle and kidney, and to a lesser extent in brain, lung, placenta and pancreas. The expression of palmitoyl-CoA ligase in various tissue parallels the function of this enzyme in the metabolism of fatty acids in these tissues.

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页码：77 / 81

页数：5

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