DRUG PROTEIN CONJUGATES .2. AN INVESTIGATION OF THE IRREVERSIBLE BINDING AND METABOLISM OF 17-ALPHA-ETHINYL ESTRADIOL INVIVO

被引:14
作者
MAGGS, JL [1 ]
GRABOWSKI, PS [1 ]
PARK, BK [1 ]
机构
[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND
关键词
D O I
10.1016/0006-2952(83)90559-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:301 / 308
页数:8
相关论文
共 38 条
[1]   EFFECT OF ANTIBIOTICS ON ENTEROHEPATIC CIRCULATION OF ETHINYLESTRADIOL AND NORETHISTERONE IN RAT [J].
BACK, DJ ;
BRECKENRIDGE, AM ;
CHALLINER, M ;
CRAWFORD, FE ;
ORME, ML ;
ROWE, PH ;
SMITH, E .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1978, 9 (06) :527-531
[2]  
BEAUMONT JL, 1976, CLIN EXP IMMUNOL, V24, P455
[3]  
BEAUMONT V, 1981, J MED, V12, P51
[4]   STUDIES ON METABOLISM OF ETHYNYLESTRADIOL IN-VITRO AND IN-VIVO - SIGNIFICANCE OF 2-HYDROXYLATION AND FORMATION OF POLAR PRODUCTS [J].
BOLT, HM ;
KAPPUS, H ;
REMMER, H .
XENOBIOTICA, 1973, 3 (12) :773-785
[5]   METABOLISM OF 17 ALPHA-ETHYNYLESTRADIOL BY HUMAN LIVER-MICROSOMES INVITRO - AROMATIC HYDROXYLATION AND IRREVERSIBLE PROTEIN-BINDING OF METABOLITES [J].
BOLT, HM ;
KAPPUS, H ;
KASBOHRER, R .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1974, 39 (06) :1072-1080
[6]   IRREVERSIBLE BINDING OF ETHYNYL-ESTRADIOL METABOLITES TO PROTEIN AND NUCLEIC-ACIDS AS CATALYZED BY RAT-LIVER MICROSOMES AND MUSHROOM TYROSINASE [J].
BOLT, HM ;
KAPPUS, H .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1974, 5 (02) :179-184
[7]  
BOOBIS AR, 1977, MOL PHARMACOL, V13, P259
[8]  
BRECKENRIDGE AM, 1981, BRIT J PHARMACOL, V74, pP240
[9]  
BROWN IC, 1981, BRIT J PHARMACOL, V74, pP987
[10]  
CONNEY AH, 1967, PHARMACOL REV, V19, P316