THE INFLUENCE OF AGE ON THE PHARMACOKINETICS OF VERAPAMIL

被引：13

作者：

AHMED, JH ^{[1
]}

MEREDITH, PA ^{[1
]}

ELLIOTT, HL ^{[1
]}

机构：

[1] UNIV GLASGOW,STOBHILL GEN HOSP,DEPT MED & THERAPEUT,GLASGOW G21 3UW,SCOTLAND

来源：

PHARMACOLOGICAL RESEARCH | 1991年 / 24卷 / 03期

关键词：

AGE; VERAPAMIL PHARMACOKINETICS; STEADY STATE;

D O I：

10.1016/1043-6618(91)90085-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of age on the pharmacokinetics of verapamil at steady state has been studied in 74 individuals, age range 19-79 years, including healthy normotensive volunteers and patients with essential hypertension. The peak plasma concentrations (Cmax) of verapamil were significantly higher in older subjects (r = 0.24; P = 0.03) and there was a non-significant age-related decrease in clearance/F and a non-significant increase in elimination half-life. These results suggest that increasing age is associated with changes in the pharmacokinetics of verapamil but these changes are small and unlikely to be of clinical significance. © 1991 The Italian Pharmacological Society.

引用

页码：227 / 233

页数：7

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