CHRONIC EXPOSURE TO LOW CONCENTRATIONS OF HYDROGEN-SULFIDE PRODUCES ABNORMAL GROWTH IN DEVELOPING CEREBELLAR PURKINJE-CELLS

被引:28
作者
HANNAH, RS [1 ]
ROTH, SH [1 ]
机构
[1] UNIV CALGARY,DEPT PHARMACOL & THERAPEUT,CALGARY T2N 1N4,ALBERTA,CANADA
关键词
HYDROGEN SULFIDE; DEVELOPMENT; CEREBELLUM; PURKINJE CELL; RAT;
D O I
10.1016/0304-3940(91)90864-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hydrogen sulfide (H2S) may produce deleterious effects on the developing central nervous system. The dendritic fields of developing cerebellar Purkinje cells were analyzed to determine the effects of chronic exposure to low concentrations of H2S during perinatal development. Treatment with two concentrations (20 and 50 ppm) of H2S produced severe alterations in the architecture and growth characteristics of the Purkinje cell dendritic fields. The architectural modifications included longer branches, an increase in the vertex path length and variations in the number of branches in particular areas of the dendritic field. The treated cells also exhibited a nonsymmetrical growth pattern at a time when random terminal branching is normally occurring. These findings suggest that developing neurons exposed to low concentrations of H2S are at risk of severe deficits.
引用
收藏
页码:225 / 228
页数:4
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