CHANGES IN NEUROTRANSMITTER PARAMETERS IN THE BRAIN INDUCED BY L-CYSTEINE INJECTIONS IN THE YOUNG-RAT

被引:6
作者
FONNUM, F
MALTHESORENSSEN, D
LUNDKARLSEN, R
ODDAN, E
机构
[1] Norwegian Defence Research Establishment, Division for Environmental Toxicology
关键词
L-CYSTEINE; NEUROTOXICITY; NEUROTRANSMITTER CHANGE;
D O I
10.1016/0006-8993(92)90743-S
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A single subcutaneous injection of L-cysteine (1.2 mg/g body wt.) to 4-day-old rats leads to atrophy of the brains examined 27-31 days later. The brains could be separated into two groups (type 1 and 2) on account of the degree of atrophy. Type-1 lesion, with a brain weight reduction of 20%, was dominated by a severe reduction in high-affinity uptake of L-glutamate in CNS regions receiving corticofugal fibers such as thalamus and striatum. Glutamate decarboxylase was only reduced in cortical structures. In type-2 lesion, with a severe brain atrophy of about 50%, high-affinity glutamate uptake was further reduced and there was a more pronounced reduction in glutamate decarboxylase activity in several brain regions. Cholinergic neurons were less affected by the lesion and the levels of choline acetyltransferase showed a relative increase in brain regions which partly compensated for their reduction in size.
引用
收藏
页码:74 / 78
页数:5
相关论文
共 20 条
[1]   INSITU INJECTION OF KAINIC ACID - NEW METHOD FOR SELECTIVELY LESIONING NEURONAL CELL BODIES WHILE SPARING AXONS OF PASSAGE [J].
COYLE, JT ;
MOLLIVER, ME ;
KUHAR, MJ .
JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 180 (02) :301-323
[2]  
DO KG, 1975, J NEUROCHEM, V24, P407
[3]   GLUTAMATE DECARBOXYLASE IN INHIBITORY NEURONS - A STUDY OF ENZYME IN PURKINJE CELL AXONS AND BOUTONS IN CAT [J].
FONNUM, F ;
STORMMAT.J ;
WALBERG, F .
BRAIN RESEARCH, 1970, 20 (02) :259-+
[4]  
FONNUM F, J NEUROOCHEM, V42, P1
[5]  
FONNUM F, 1977, NATURE, V266, P377
[6]  
FONNUM F, 1988, HDB EXPTL PHARM, V86, P599
[7]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[8]  
LUND KR, 1978, J NEUROCHEM, V31, P301
[9]  
LUNDKARLSEN R, 1978, BRAIN RES, V151, P457
[10]  
LUNDKARLSEN R, 1981, BRAIN RES, V208, P167