MOUSE HEPATIC-MICROSOMAL OXIDATION OF ALIPHATIC-ALDEHYDES (C8 TO C-11) TO CARBOXYLIC-ACIDS

被引:12
作者
WATANABE, K
MATSUNAGA, T
NARIMATSU, S
YAMAMOTO, I
YOSHIMURA, H
机构
[1] HOKURIKU UNIV,FAC PHARMACEUT SCI,DEPT HYG CHEM,KANAZAWA,ISHIKAWA 92011,JAPAN
[2] NAKAMURA GAKUEN COLL,DEPT FOOD & NUTR,FUKUOKA 81401,JAPAN
关键词
D O I
10.1016/0006-291X(92)92357-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Addition of saturated and α, β-unsaturated aliphatic aldehydes (C8 to C11) significantly increased NADPH oxidation with mouse hepatic microsomes, and the aldehydes themselves were oxidized to the corresponding carboxylic acids. When these aldehyde substrates were incubated similarly under oxygen-18 gas and the carboxylic acids formed were analyzed by GC-MS after methylation, it was indicated that oxygen-18 was significantly incorporated into the carboxylic acids formed from α,β-unsaturated aldehydes, but not significantly into the carboxylic acids formed from saturated aldehydes. These results indicate that enzyme and/or mechanism responsible for the oxidation of these two types of aldehydes is different from each other. © 1992.
引用
收藏
页码:114 / 119
页数:6
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