DEMONSTRATION OF THE MYOCARDIAL SALVAGE EFFECT OF LITHOSPERMIC ACID-B ISOLATED FROM THE AQUEOUS EXTRACT OF SALVIA-MILTIORRHIZA

被引：50

作者：

FUNG, KP

ZENG, LH

WU, J

WONG, HNC

LEE, CM

HON, PM

CHANG, HM

WU, TW

机构：

[1] UNIV TORONTO, DEPT CLIN BIOCHEM, ES 3-404B, 200 ELIZABETH ST, TORONTO M5G 2C4, ON, CANADA

[2] CTR CARDIOVASC RES, TORONTO, ON, CANADA

[3] TORONTO GEN HOSP, TORONTO M5G 2C4, ON, CANADA

[4] CHINESE UNIV HONG KONG, DEPT CHEM, SHA TIN, HONG KONG

[5] CHINESE UNIV HONG KONG, DEPT BIOCHEM, SHA TIN, HONG KONG

[6] CHINESE UNIV HONG KONG, CHINESE MED MAT RES CTR, SHA TIN, HONG KONG

来源：

LIFE SCIENCES | 1993年 / 52卷 / 22期

关键词：

D O I：

10.1016/0024-3205(93)90471-E

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lithospermic acid B has been isolated to > 95% purity by high performance liquid chromatography from the aqueous extract of the roots of Salvia miltiorrhiza. When infused at 5.5 mumoles/kg into the post-ischemic rabbit heart, it reduced by 62 +/- 10% (n = 8) the myocardial damage found in the saline control in a rabbit ischemia-reperfusion model.

引用

页码：PL239 / PL244

页数：6

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