HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF C-11 LABELED THYMIDINE AND ITS MAJOR CATABOLITES FOR CLINICAL PET STUDIES

被引：27

作者：

CONTI, PS

HILTON, J

WONG, DF

ALAUDDIN, MM

DANNALS, RF

RAVERT, HT

WILSON, AA

ANDERSON, JH

机构：

[1] JOHNS HOPKINS MED INST, DEPT RADIOL & RADIOL SCI, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS MED INST, CTR ONCOL, BALTIMORE, MD 21205 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1994年 / 21卷 / 08期

关键词：

D O I：

10.1016/0969-8051(94)90176-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The identity and pharmacology of the rapidly formed radiolabeled metabolites formed following i.v. injection of C-11 thymidine (TdR) labeled in the 5-methyl-position are being studied in animal models and patients with cancer. A high performance liquid chromatographic (HPLC) procedure has been developed for the separation of these metabolites including thymine, dihydrothymine, beta-ureidoisobutyric acid, and beta-aminoisobutyric acid from plasma and tissue extracts. Information obtained regarding the pharmacokinetics of the metabolites are being used to generate mathematical models for C-11 TdR incorporation rates into DNA.

引用

页码：1045 / 1051

页数：7

共 33 条

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