A MUTANT CHO-K1 STRAIN WITH RESISTANCE TO PSEUDOMONAS EXOTOXIN-A IS UNABLE TO PROCESS THE PRECURSOR FUSION GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS

被引：14

作者：

INOCENCIO, NM

MOEHRING, JM

MOEHRING, TJ

机构：

[1] UNIV VERMONT, MARKEY CTR MOLEC GENET, DEPT MICROBIOL & MOLEC GENET, BURLINGTON, VT 05405 USA

[2] UNIV VERMONT, VERMONT CANC CTR, BURLINGTON, VT 05405 USA

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 01期

关键词：

D O I：

10.1128/JVI.67.1.593-595.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RPE.40, a mutant strain of CHO-K1 cells isolated for resistance to Pseudomonas exotoxin A and cross-resistant to alphaviruses, is also highly resistant to virulent strains of Newcastle disease virus. The resistance of RPE.40 cells to Newcastle disease virus results from the failure to cleave the viral envelope precursor glycoprotein Fo to fusion glycoprotein F1 at the consensus sequence (Lys/Arg)-Arg-Gln-(Lys/Arg)-Arg.

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页码：593 / 595

页数：3

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