UNPRECEDENTED MIGRATION OF [PT(DIEN)]2+ (DIEN = 1,5-DIAMINO-3-AZAPENTANE) FROM SULFUR TO GUANOSINE-N7 IN S-GUANOSYL-L-HOMOCYSTEINE (SGH)

被引：92

作者：

VANBOOM, SSGE ^{[1
]}

REEDIJK, J ^{[1
]}

机构：

[1] LEIDEN UNIV,GORLAEUS LABS,INST CHEM,POB 9502,2300 RA LEIDEN,NETHERLANDS

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 18期

关键词：

D O I：

10.1039/c39930001397

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The species [Pt(dien)(sgh-S)]2+ 1 formed upon reaction of sgh with one equivalent of [PtCl(dien)CI at 2 < pH < 6.5 is found to isomerize intramolecularly into [Pt(dien)(sgh-N7)]2+ 2 with Pt coordination at N7 of guanosine; upon addition of a second equivalent of [PtCl(dien)]Cl dinuclear [{Pt(dien)}2(sgh-N7,S)]4+ 3 is formed.

引用

页码：1397 / 1398

页数：2

共 11 条

[1] NMR-STUDY OF THE REACTIONS OF THE CIS-DIAMMINEDIAQUAPLATINUM(II) CATION WITH GLUTATHIONE AND AMINO-ACIDS CONTAINING A THIOL-GROUP
APPLETON, TG
CONNOR, JW
HALL, JR
PRENZLER, PD
[J]. INORGANIC CHEMISTRY, 1989, 28 (11) : 2030 - 2037
[2] REACTION OF CIS-[PTCL2(NH3)2] AND TRANS-[PTCL2(NH3)2] WITH REDUCED GLUTATHIONE STUDIED BY H-1-[H-1], C-13[H-1], PT-195[H-1] AND N-15-[H-1] DEPT NMR
BERNERSPRICE, SJ
KUCHEL, PW
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1990, 38 (04) : 305 - 326
[3] INHIBITION OF CIS-PLATINUM NEPHROTOXICITY BY DIETHYLDITHIOCARBAMATE RESCUE IN A RAT MODEL
BORCH, RF
PLEASANTS, ME
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (12) : 6611 - 6614
[4] INTERACTION OF CIS-[PT(NH3)2(H2O)2](NO3)2 WITH RIBOSE DINUCLEOSIDE MONOPHOSPHATES
CHOTTARD, JC
GIRAULT, JP
CHOTTARD, G
LALLEMAND, JY
MANSUY, D
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (17) : 5565 - 5572
[5] CROSS-LINKING OF GLUTATHIONE TO DNA BY CANCER CHEMOTHERAPEUTIC PLATINUM COORDINATION-COMPLEXES
EASTMAN, A
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1987, 61 (03) : 241 - 248
[6] HILDESHEIM J, 1972, BIOCHIMIE, V54, P432
[7] STRUCTURES OF THE ADDUCTS FORMED BETWEEN [PT(DIEN)C1]C1 AND DNA INVITRO
JOHNSON, NP
MACQUET, JP
WIEBERS, JL
MONSARRAT, B
[J]. NUCLEIC ACIDS RESEARCH, 1982, 10 (17) : 5255 - 5271
[8] REVERSIBILITY OF BINDING OF CISPLATIN METHIONINE IN PROTEINS BY DIETHYLDITHIOCARBAMATE OR THIOUREA - A STUDY WITH MODEL ADDUCTS
LEMPERS, ELM
REEDIJK, J
[J]. INORGANIC CHEMISTRY, 1990, 29 (02) : 217 - 222
[9] CHARACTERIZATION OF PRODUCTS FROM [PTCL(DIEN)]CL AND S-ADENOSYL-L-HOMOCYSTEINE - EVIDENCE FOR A PH-DEPENDENT MIGRATION OF THE PLATINUM MOIETY FROM THE SULFUR ATOM TO THE AMINE GROUP AND VICE-VERSA
LEMPERS, ELM
REEDIJK, J
[J]. INORGANIC CHEMISTRY, 1990, 29 (10) : 1880 - 1884
[10] STUDIES OF PLATINUM(II) METHIONINE COMPLEXES - METABOLITES OF CISPLATIN
NORMAN, RE
RANFORD, JD
SADLER, PJ
[J]. INORGANIC CHEMISTRY, 1992, 31 (05) : 877 - 888

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