STUDIES ON TESTOSTERONE METABOLISM .6. PRECURSORS OF URINARY ANDROSTANEDIOLS

被引：21

作者：

MAUVAISJARVIS, P

FLOCH, H

JUNG, I

ROBEL, P

BAULIEU, EE

机构：

[1] Unite de Recherches sur le Metabolisme Moleculaire et la Physio-Pathologie des Steroides, 1'Institut National de la Santé, la Recherche Médicale - Service

来源：

STEROIDS | 1968年 / 11卷 / 02期

关键词：

D O I：

10.1016/0039-128X(68)90009-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radioactive testosterone, 17β-hydroxy-5α and β-androstan-3-one, androsterone, 5α-androstane-3,17-dione and Δ4-androstene-3α and β, 17β-diol have been injected into normal men and women, and the urinary radioactive 17-oxo and 17β-hydroxyandrostane steroids have been isolated. 17β-hydroxy-5α-andros-tan -3-one has been found in the glucuronide fraction. Results indicate that 17β-hydroxy-5α and β-androstan-3-one are good precursors of urinary 5α and β-androstane-3α, 17β-diol respectively; it seems probable that they are intermediates in the formation of the androstanediols from testosterone whereas most urinary 17-oxosteroids deriving from testosterone are formed after dehydrogenation of testosterone to Δ4-androstene-3,17-dione. Δ4-androstene-3α and β, 17β-diols are essentially converted into testosterone. © 1968.

引用

页码：207 / +

页数：1

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