NEURONAL INTERMEDIATE FILAMENTS IN RAT DORSAL-ROOT GANGLIA - DIFFERENTIAL DISTRIBUTION OF PERIPHERIN AND NEUROFILAMENT PROTEIN IMMUNOREACTIVITY AND EFFECT OF CAPSAICIN

被引：58

作者：

FERRI, GL

SABANI, A

ABELLI, L

POLAK, JM

DAHL, D

PORTIER, MM

机构：

[1] MENARINI SUD, DEPT PHARMACOL, POMEZIA, ITALY

[2] COLL FRANCE, BIOCHIM CELLULAIRE LAB, F-75231 PARIS 05, FRANCE

[3] HARVARD UNIV, SCH MED, DEPT NEUROPATHOL, BOSTON, MA 02115 USA

[4] HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, DEPT HISTOCHEM, LONDON W12 0HS, ENGLAND

[5] VET ADM MED CTR W ROXBURY, BOSTON, MA 02132 USA

来源：

BRAIN RESEARCH | 1990年 / 515卷 / 1-2期

关键词：

Capsaicin; Intermediate filament; Neurofilament protein; Peripherin; Sensory neuron; Spinal ganglia;

D O I：

10.1016/0006-8993(90)90618-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two major neuronal populations were revealed in rat dorsal root ganglia, immunoreactive for either peripherin, or neurofilament triplet proteins (adult L2 ganglia: 66.2% and 25.6%, mainly small and large diameter cells, respectively), together with a minor, double-immunostained population (L2: 8.1%, mainly intermediate-size neurons). After capsaicin treatment, a striking expansion in the latter population was seen (L2: 22.0%) together with a significant increase in size, restricted to the same population and the (remaining) peripherin-only immunoreactive neurons. Calcitonin gene-related peptide (CGRP) immunoreactivity was revealed in neurons of all 3 groups, in both normal and capsaicin-treated rats. © 1990.

引用

页码：331 / 335

页数：5

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