MORPHINE-METABOLISM IN NEONATES AND INFANTS

被引：49

作者：

CHOONARA, I

LAWRENCE, A

MICHALKIEWICZ, A

BOWHAY, A

RATCLIFFE, J

机构：

[1] PAIN RELIEF FDN,LIVERPOOL,ENGLAND

[2] ALDER HEY CHILDRENS HOSP,REG PAEDIAT INTENS CARE UNIT,LIVERPOOL L12 2AP,MERSEYSIDE,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 34卷 / 05期

关键词：

MORPHINE; GLUCURONIDATION; NEONATES; INFANTS;

D O I：

10.1111/j.1365-2125.1992.tb05652.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphine was 20.1 ml min-1 kg-1 in neonates and 23.4 ml min-1 kg-1 in the group as a whole. The M3G/morphine ratio (7.3) was higher than that previously reported for preterm neonates (5.0) but lower than that reported for children (23.9).

引用

页码：434 / 437

页数：4

共 22 条

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