CYTOADHERENCE-RELATED HOMOLOGOUS MOTIFS IN PLASMODIUM-FALCIPARUM ANTIGEN PF155/RESA AND ERYTHROCYTE BAND-3 PROTEIN

被引：11

作者：

IQBAL, J ^{[1
]}

SIDDIQUE, AB ^{[1
]}

AHLBORG, N ^{[1
]}

PERLMANN, P ^{[1
]}

BERZINS, K ^{[1
]}

机构：

[1] UNIV STOCKHOLM, DEPT IMMUNOL, S-10691 STOCKHOLM, SWEDEN

来源：

PARASITOLOGY | 1995年 / 110卷

关键词：

PLASMODIUM FALCIPARUM; PF155/RESA; BAND; 3; PROTEIN; CYTOADHERENCE; SYNTHETIC PEPTIDES;

D O I：

10.1017/S0031182000065215

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Cytoadherence of Plasmodium falciparum-infected erythrocytes plays an important role in the pathogenesis of cerebral malaria. The identity of cell surface molecules on parasitized erythrocytes involved in cytoadherence is of great interest to understand the molecular basis of this mechanism. Peptide sequences derived from exofacial loops of the erythrocyte antigen band 3 from parasitized erythrocytes have previously been shown to inhibit cytoadherence. We now report that a non-repeated region of Pf155/RESA (residues 213-218) contains a hexapeptide motif being highly homologous to cytoadherence inhibitory sequences from band 3. Synthetic peptides containing the hexapeptide motif of Pf155/RESA inhibited the binding of P. falciparum-infected erythrocytes to melanoma cells in vitro. Furthermore, individuals residing in malaria-endemic areas have antibodies reactive with epitopes involving these motifs in band 3 and in Pf155/RESA.

引用

页码：503 / 511

页数：9

共 46 条

[1] HUMAN CEREBRAL MALARIA [J].

AIKAWA, M .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1988, 39 (01) :3-10

[2] PF155/RESA ANTIGEN IS LOCALIZED IN DENSE GRANULES OF PLASMODIUM-FALCIPARUM MEROZOITES [J].

AIKAWA, M ;

TORII, M ;

SJOLANDER, A ;

BERZINS, K ;

PERLMANN, P ;

MILLER, LH .

EXPERIMENTAL PARASITOLOGY, 1990, 71 (03) :326-329

[3]

ANDERS RF, 1987, MOL STRATEGIES PARAS, P333

[4] RABBIT AND HUMAN-ANTIBODIES TO A REPEATED AMINO-ACID-SEQUENCE OF PLASMODIUM-FALCIPARUM ANTIGEN, PF-155, REACT WITH THE NATIVE PROTEIN AND INHIBIT MEROZOITE INVASION [J].

BERZINS, K ;

PERLMANN, H ;

WAHLIN, B ;

CARLSSON, J ;

WAHLGREN, M ;

UDOMSANGPETCH, R ;

BJORKMAN, A ;

PATARROYO, ME ;

PERLMANN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :1065-1069

[5] PFL55/RESA IS NOT A SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES [J].

BERZINS, K .

PARASITOLOGY TODAY, 1991, 7 (08) :193-194

[6] ANTIGENIC VARIATION IN PLASMODIUM-FALCIPARUM [J].

BIGGS, BA ;

GOOZE, L ;

WYCHERLEY, K ;

WOLLISH, W ;

SOUTHWELL, B ;

LEECH, JH ;

BROWN, GV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) :9171-9174

[7] EXPRESSION OF THE RESA GENE IN PLASMODIUM-FALCIPARUM ISOLATE FCR3 IS PREVENTED BY A SUBTELOMERIC DELETION [J].

CAPPAI, R ;

VANSCHRAVENDIJK, MR ;

ANDERS, RF ;

PETERSON, MG ;

THOMAS, LM ;

COWMAN, AF ;

KEMP, DJ .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (08) :3584-3587

[8] STUDIES ON PF155/RESA AND OTHER SOLUBLE-ANTIGENS FROM INVITRO CULTURED PLASMODIUM-FALCIPARUM [J].

CARLSSON, J ;

BERZINS, K ;

PERLMANN, H ;

PERLMANN, P .

PARASITOLOGY RESEARCH, 1991, 77 (01) :27-32

[9] IMMUNIZATION WITH SYNTHETIC PEPTIDES OF A PLASMODIUM-FALCIPARUM SURFACE-ANTIGEN INDUCES ANTIMEROZOITE ANTIBODIES [J].

CHEUNG, A ;

LEBAN, J ;

SHAW, AR ;

MERKLI, B ;

STOCKER, J ;

CHIZZOLINI, C ;

SANDER, C ;

PERRIN, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8328-8332

[10] SYNTHETIC PEPTIDES BASED ON MOTIFS PRESENT IN HUMAN BAND-3 PROTEIN INHIBIT CYTOADHERENCE SEQUESTRATION OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].

CRANDALL, I ;

COLLINS, WE ;

GYSIN, J ;

SHERMAN, IW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4703-4707

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