NA+ CHANNELS ARE EXPRESSED BY MAMMALIAN RETINAL GLIAL (MULLER) CELLS

被引：18

作者：

CHAO, TI ^{[1
]}

PANNICKE, T ^{[1
]}

REICHELT, W ^{[1
]}

REICHENBACH, A ^{[1
]}

机构：

[1] UNIV LEIPZIG,CARL LUDWIG INST PHYSIOL,LIEBIGSTR 27,O-7010 LEIPZIG,GERMANY

来源：

NEUROREPORT | 1993年 / 4卷 / 05期

关键词：

GLIA; MULLER CELLS; MAMMALIAN RETINA; NA+ CHANNELS; VOLTAGE CLAMP; WHOLE CELL RECORDING;

D O I：

10.1097/00001756-199305000-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MULLER cells constitute the principal glia of the vertebrate retina. Unlike other types of neuroglial cells such as astrocytes and Schwann cells, Muller cells have not yet been demonstrated to express Na+ channels. Here we present first evidence of Muller cell Na+ currents from voltage-clamp studies in enzymatically isolated cells. Some cells from retinae of cats and dogs, but none from rabbit or guinea-pig retinae, revealed fast and rapidly inactivating inward currents in response to depolarizing voltage steps. The currents reversibly disappeared in Na+ free solutions or under tetrodotoxin (TTX, 1 muM). Activation and inactivation characteristics of these currents were strikingly similar to those of neurone-type Na+ channels.

引用

页码：575 / 578

页数：4

共 25 条

[1]

BARRES BA, 1990, ANNU REV NEUROSCI, V13, P441, DOI 10.1146/annurev.ne.13.030190.002301

[2] ION CHANNEL EXPRESSION BY WHITE MATTER GLIA - THE O-2A GLIAL PROGENITOR-CELL [J].

BARRES, BA ;

KOROSHETZ, WJ ;

SWARTZ, KJ ;

CHUN, LLY ;

COREY, DP .

NEURON, 1990, 4 (04) :507-524

[3] ION CHANNEL EXPRESSION BY WHITE MATTER GLIA .1. TYPE-2 ASTROCYTES AND OLIGODENDROCYTES [J].

BARRES, BA ;

CHUN, LLY ;

COREY, DP .

GLIA, 1988, 1 (01) :10-30

[4] THE PRESENCE OF VOLTAGE-GATED SODIUM, POTASSIUM AND CHLORIDE CHANNELS IN RAT CULTURED ASTROCYTES [J].

BEVAN, S ;

CHIU, SY ;

GRAY, PTA ;

RITCHIE, JM .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1985, 225 (1240) :299-313

[5] ENDFEET OF RETINAL GLIAL-CELLS HAVE HIGHER DENSITIES OF ION CHANNELS THAT MEDIATE K+ BUFFERING [J].

BREW, H ;

GRAY, PTA ;

MOBBS, P ;

ATTWELL, D .

NATURE, 1986, 324 (6096) :466-468

[6]

CHAO TI, 1993, IN PRESS J PHYSL LON

[7] THE EVOLUTION OF RETINAL VASCULARIZATION IN MAMMALS - A COMPARISON OF VASCULAR AND AVASCULAR RETINAE [J].

CHASE, J .

OPHTHALMOLOGY, 1982, 89 (12) :1518-1525

[8] CHANGES IN EXCITABLE MEMBRANE-PROPERTIES IN SCHWANN-CELLS OF ADULT-RABBIT SCIATIC-NERVES FOLLOWING NERVE TRANSECTION [J].

CHIU, SY .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 396 :173-188

[9] NEURONAL-TYPE NA+ AND K+ CHANNELS IN RABBIT CULTURED SCHWANN-CELLS [J].

CHIU, SY ;

SCHRAGER, P ;

RITCHIE, JM .

NATURE, 1984, 311 (5982) :156-157

[10] THE GLIAL VOLTAGE-GATED SODIUM-CHANNEL - CELL-SPECIFIC AND TISSUE-SPECIFIC MESSENGER-RNA EXPRESSION [J].

GAUTRON, S ;

DOSSANTOS, G ;

PINTOHENRIQUE, D ;

KOULAKOFF, A ;

GROS, F ;

BERWALDNETTER, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :7272-7276

← 1 2 3 →