A NONPEPTIDYL GROWTH-HORMONE SECRETAGOGUE

被引：315

作者：

SMITH, RG ^{[1
]}

CHENG, K ^{[1
]}

SCHOEN, WR ^{[1
]}

PONG, SS ^{[1
]}

HICKEY, G ^{[1
]}

JACKS, T ^{[1
]}

BUTLER, B ^{[1
]}

CHAN, WWS ^{[1
]}

CHAUNG, LYP ^{[1
]}

JUDITH, F ^{[1
]}

TAYLOR, J ^{[1
]}

WYVRATT, MJ ^{[1
]}

FISHER, MH ^{[1
]}

机构：

[1] MERCK RES LABS, DEPT BASIC MED CHEM, RAHWAY, NJ 07065 USA

来源：

SCIENCE | 1993年 / 260卷 / 5114期

关键词：

D O I：

10.1126/science.8503009

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methy1}-1H-1-benzazepin-3(R)-yl)-butanamide (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an alternative signal transduction pathway. The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). L-692,429 is an example of a nonpeptidyl specific secretagogue for growth hormone.

引用

页码：1640 / 1643

页数：4

共 24 条

[1] DESENSITIZATION STUDIES USING PERIFUSED RAT PITUITARY-CELLS SHOW THAT GROWTH HORMONE-RELEASING HORMONE AND HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2 STIMULATE GROWTH-HORMONE RELEASE THROUGH DISTINCT RECEPTOR-SITES
BLAKE, AD
SMITH, RG
[J]. JOURNAL OF ENDOCRINOLOGY, 1991, 129 (01) : 11 - 19
[2] GROWTH-HORMONE (GH)-RELEASING PEPTIDE STIMULATES GH RELEASE IN NORMAL MEN AND ACTS SYNERGISTICALLY WITH GH-RELEASING HORMONE
BOWERS, CY
REYNOLDS, GA
DURHAM, D
BARRERA, CM
PEZZOLI, SS
THORNER, MO
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (04) : 975 - 982
[3] ON THE INVITRO AND INVIVO ACTIVITY OF A NEW SYNTHETIC HEXAPEPTIDE THAT ACTS ON THE PITUITARY TO SPECIFICALLY RELEASE GROWTH-HORMONE
BOWERS, CY
MOMANY, FA
REYNOLDS, GA
HONG, A
[J]. ENDOCRINOLOGY, 1984, 114 (05) : 1537 - 1545
[4] BRIXEN K, 1990, J BONE MINER RES, V5, P609
[5] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE DISCOVERY OF A SERIES OF N-(BIPHENYLYLMETHYL)IMIDAZOLES AS POTENT, ORALLY ACTIVE ANTIHYPERTENSIVES
CARINI, DJ
DUNCIA, JV
ALDRICH, PE
CHIU, AT
JOHNSON, AL
PIERCE, ME
PRICE, WA
SANTELLA, JB
WELLS, GJ
WEXLER, RR
WONG, PC
YOO, SE
TIMMERMANS, PBMWM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) : 2525 - 2547
[6] CHENG K, 1991, ENDOCRINOLOGY, V129, P3337
[7] CHENG K, 1989, ENDOCRINOLOGY, V124, P2791
[8] CHENG K, UNPUB
[9] GROWTH-HORMONE TREATMENT IN GROWTH HORMONE-DEFICIENT ADULTS .2. EFFECTS ON EXERCISE PERFORMANCE
CUNEO, RC
SALOMON, F
WILES, CM
HESP, R
SONKSEN, PH
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1991, 70 (02) : 695 - 700
[10] GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440

← 1 2 3 →