EFFECT OF PROTEIN-KINASE INHIBITORS ON THE INVASION PROCESS OF MACROPHAGES BY TRYPANOSOMA-CRUZI

被引：39

作者：

VIEIRA, MCF ^{[1
]}

DECARVALHO, TU ^{[1
]}

DESOUZA, W ^{[1
]}

机构：

[1] FED UNIV RIO DE JANEIRO, INST BIOFIS CARLOS CHAGAS, ULTRAESTRUT CELULAR HERTHA MEYER LAB, BR-21949900 RIO DE JANEIRO, BRAZIL

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2276

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of Trypanosoma cruzi with different vertebrate cells involves two distinct steps, attachment and internalization. Genistein and staurosporine, drugs which inhibit protein kinases, specially tyrosine kinase,are able to block the infection of macrophages by T. cruzi, suggesting that protein phosphorylation is a key event on this process. (C) 1994 Academic Press, Inc.

引用

页码：967 / 971

页数：5

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