DIRECT C-13 NMR EVIDENCE FOR A TETRAHEDRAL INTERMEDIATE IN THE BINDING OF A PEPSTATIN ANALOG TO PORCINE PEPSIN

被引：80

作者：

RICH, DH

BERNATOWICZ, MS

SCHMIDT, PG

机构：

[1] UNIV OKLAHOMA,OKLAHOMA MED RES FDN,OKLAHOMA CITY,OK 73104

[2] UNIV OKLAHOMA,HLTH SCI CTR,DEPT BIOCHEM & MOLEC BIOL,OKLAHOMA CITY,OK 73104

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1982年 / 104卷 / 12期

关键词：

D O I：

10.1021/ja00376a062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：3535 / 3536

页数：2

共 14 条

[1] SOYBEAN TRYPSIN-INHIBITOR (KUNITZ) AND ITS COMPLEX WITH TRYPSIN - CARBON-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF THE REACTIVE SITE ARGININE [J].

BAILLARGEON, MW ;

LASKOWSKI, M ;

NEVES, DE ;

PORUBCAN, MA ;

SANTINI, RE ;

MARKLEY, JL .

BIOCHEMISTRY, 1980, 19 (25) :5703-5710

[2]

BERNATOWICZ MS, 1981, PEPTIDES SYNTHESIS S, P439

[3]

BOTT R, COMMUNICATION

[4] C-13-NMR STUDIES OF MUTAROTATION EQUILIBRIA OF D-FRUCTOSE AND 1-AMINO-1-DEOXY-D-FRUCTOSE DERIVATIVES (AMADORI COMPOUNDS) [J].

FUNCKE, W ;

KLEMER, A .

CARBOHYDRATE RESEARCH, 1976, 50 (01) :9-13

[5]

MARCINISZYN J, 1976, J BIOL CHEM, V251, P7088

[6]

MARSHALL GR, 1976, FED PROC, V35, P2494

[7] SYNTHESIS OF ANALOGS OF THE CARBOXYL PROTEASE INHIBITOR PEPSTATIN - EFFECT OF STRUCTURE ON INHIBITION OF PEPSIN AND RENIN [J].

RICH, DH ;

SUN, ETO ;

ULM, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (01) :27-33

[8] MECHANISM OF INHIBITION OF PEPSIN BY PEPSTATIN - EFFECT OF INHIBITOR STRUCTURE ON DISSOCIATION-CONSTANT AND TIME-DEPENDENT INHIBITION [J].

RICH, DH ;

SUN, ETO .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (16) :2205-2212

[9] SYNTHESIS OF A 3-OXO-4(S)-AMINO ACID ANALOG OF PEPSTATIN - A NEW INHIBITOR OF CARBOXYL (ACID) PROTEASES [J].

RICH, DH ;

BOPARAI, AS ;

BERNATOWICZ, MS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 104 (03) :1127-1133

[10] C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF THE SELECTIVELY ISOTOPE-LABELED REACTIVE SITE PEPTIDE-BOND OF THE BASIC PANCREATIC TRYPSIN-INHIBITOR IN THE COMPLEXES WITH TRYPSIN, TRYPSINOGEN, AND ANHYDROTRYPSIN [J].

RICHARZ, R ;

TSCHESCHE, H ;

WUTHRICH, K .

BIOCHEMISTRY, 1980, 19 (25) :5711-5715

← 1 2 →