A LARGE DOMAIN COMMON TO SPERM RECEPTORS (ZP2 AND ZP3) AND TGF-BETA TYPE-III RECEPTOR

被引：288

作者：

BORK, P

SANDER, C

机构：

[1] EMBL, 6900 Heidelberg, Meyerhofstr

来源：

FEBS LETTERS | 1992年 / 300卷 / 03期

关键词：

HOMOLOGY; MOSAIC PROTEIN; SPERM RECEPTOR; TGF-RECEPTOR; UROMODULIN;

D O I：

10.1016/0014-5793(92)80853-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also called TGF-beta type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-beta receptor complex.

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页码：237 / 240

页数：4

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