INORGANIC PYROPHOSPHATE IN METABOLIC DISEASES PREDISPOSING TO CALCIUM PYROPHOSPHATE DIHYDRATE CRYSTAL DEPOSITION

被引:28
作者
DOHERTY, M [1 ]
CHUCK, A [1 ]
HOSKING, D [1 ]
HAMILTON, E [1 ]
机构
[1] CITY HOSP NOTTINGHAM,DEPT MED,NOTTINGHAM NG5 1PB,ENGLAND
来源
ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 10期
关键词
D O I
10.1002/art.1780341014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inorganic pyrophosphate (PP(i)) levels were estimated by radiometric assay in urine and in synovial fluid (SF) from asymptomatic, nonarthritic knees of patients with untreated metabolic disease and normal controls. SF PP(i) was significantly elevated in patients with hyperparathyroidism (mean +/- SEM 19 +/- 3-mu-M; n = 9), hemochromatosis (23 +/- 5-mu-M; n = 6), and hypomagnesemia (27 +/- 0.1-mu-M; n = 2) compared with normal subjects (10 +/- 0.5-mu-M, n = 50), and was low in patients with hypothyroidism (4.2 +/- 2.3-mu-M; n = 11) (P < 0.05 all comparisons). Urinary PP(i) was elevated only in those with hypophosphatasia. Local elevation of ionic PP(i) may be relevant to the mechanism of crystal formation in metabolic diseases predisposing to calcium pyrophosphate dihydrate (CPPD) crystal deposition. The finding of low SF PP(i) levels in patients with hypothyrodism further questions the association between this condition and CPPD.
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页码:1297 / 1303
页数:7
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