SULFONYLUREAS - A NEW CLASS OF CANCER CHEMOTHERAPEUTIC-AGENTS

被引：57

作者：

MOHAMADI, F ^{[1
]}

SPEES, MM ^{[1
]}

GRINDEY, GB ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 16期

关键词：

D O I：

10.1021/jm00094a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study summarizes the antitumor properties of a number of sulofenur thiophene analogs against subcutaneously implanted 6C3HED lymphosarcoma with structural modification of the aryl moiety of the sulfonamide portion of the diarylsulfonylureas. The spectrum of activity of N-(p-chlorophenyl)-N'-[(5-methoxy-2-thienyl)sulfonyl]urea in the HXGC3, VRC5, CX-1, and LX-1 cell lines is also presented.

引用

页码：3012 / 3016

页数：5

共 26 条

[1]

BINDER D, 1977, SYNTHESIS-STUTTGART, P255

[2]

BODER G B, 1989, Proceedings of the American Association for Cancer Research Annual Meeting, V30, P554

[3] SYNTHESIS OF SOME THIOPHENIUM BIS(TERT-BUTOXYCARBONYL)METHYLIDES [J].

BOWLES, T ;

JONES, R ;

PORTER, AEA ;

RECHKA, JA ;

RZEPA, HS ;

WILLIAMS, DJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (05) :1023-1027

[4]

DENEMOURS EID, 1983, Patent No. 4368067

[5]

EHLHARDT WJ, 1991, DRUG METAB DISPOS, V19, P370

[6]

GRINDEY GB, 1987, P AM ASSOC CANC RES, V28, P309

[7]

GRINDEY GB, 1988, P AM ASSOC CANC RES, V29, P535

[8]

HAINSWORTH JD, 1989, CANCER RES, V49, P5217

[9]

HERRMANN R, 1991, Proceedings of the American Association for Cancer Research Annual Meeting, V32, P403

[10]

HOUGHTON P J, 1989, Proceedings of the American Association for Cancer Research Annual Meeting, V30, P577

← 1 2 3 →