SELECTIVE-INHIBITION OF STEROID 5-ALPHA-REDUCTASE ISOZYMES BY TEA EPICATECHIN-3-GALLATE AND EPIGALLOCATECHIN-3-GALLATE

被引：122

作者：

LIAO, SS ^{[1
]}

HIIPAKKA, RA ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibitors of 5 alpha-reductase may be effective in the treatment of 5 alpha-dihydrotestosterone-dependent abnormalities, such as benign prostate hyperplasia, prostate cancer and certain skin diseases. The green tea catechins, (-)epigallocatechin-3-gallate and (-)epicatechin-3-gallate, but not (-)epicatechin and (-)epigallocatechin, are potent inhibitors of type 1 but not type 2 5 alpha-reductase. (-)Epigallocatechin-3-gallate also inhibits accessory sex gland growth in the rat. These results suggest that certain tea gallates can regulate androgen action in target organs. (C) 1995 Academic Press, Inc.

引用

页码：833 / 838

页数：6

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