RESOLUTION OF (+/-)-2-TETRADECYLOXIRANECARBOXYLIC ACID - ABSOLUTE-CONFIGURATION AND CHIRAL SYNTHESIS OF THE HYPOGLYCEMIC R ENANTIOMER AND BIOLOGICAL-ACTIVITY OF ENANTIOMERS

被引：19

作者：

HO, W ^{[1
]}

TARHAN, O ^{[1
]}

KIORPES, TC ^{[1
]}

TUTWILER, GF ^{[1
]}

MOHRBACHER, RJ ^{[1
]}

机构：

[1] MCNEIL PHARMACEUT,DEPT BIOL RES,SPRING HOUSE,PA 19477

来源：

关键词：

D O I：

10.1021/jm00389a020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1094 / 1097

页数：4

共 14 条

[1] CIARDELLI T, 1981, LIEBIGS ANN CHEM, P828
[2] ALKYLGLYCIDIC ACIDS - POTENTIAL NEW HYPOGLYCEMIC AGENTS
HO, W
TUTWILER, GF
COTTRELL, SC
MORGANS, DJ
TARHAN, O
MOHRBACHER, RJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) : 2184 - 2190
[3] KATSUKI T, 1980, J AM CHEM SOC, V102, P5976
[4] KIORPES TC, 1984, J BIOL CHEM, V259, P9750
[5] SHARPLESS, 1984, J ORG CHEM, V49, P731
[6] Shaw E., 1970, ENZYMES, V1, P91
[7] Tutwiler G F, 1981, Methods Enzymol, V72, P533
[8] PHARMACOLOGIC PROFILE OF METHYL 2-TETRADECYLGLYCIDATE (MCN-3716) - ORALLY EFFECTIVE HYPOGLYCEMIC AGENT
TUTWILER, GF
KIRSCH, T
MOHRBACHER, RJ
HO, W
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1978, 27 (10): : 1539 - 1556
[9] METHYL 2-TETRADECYLGLYCIDATE, AN ORALLY EFFECTIVE HYPOGLYCEMIC AGENT THAT INHIBITS LONG-CHAIN FATTY-ACID OXIDATION SELECTIVELY
TUTWILER, GF
MOHRBACHER, R
HO, W
[J]. DIABETES, 1979, 28 (03) : 242 - 248
[10] TUTWILER GF, 1979, J BIOL CHEM, V254, P2935