EFFECTS OF MELATONIN ON GENETIC HYPERCHOLESTEROLEMIA IN RATS

被引：28

作者：

AOYAMA, H

MORI, N

MORI, W

机构：

[1] UNIV TOKYO, FAC MED, DEPT PATHOL, ANAT 2, TOKYO 113, JAPAN

[2] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 3, ANAT 2, TOKYO 113, JAPAN

来源：

ATHEROSCLEROSIS | 1988年 / 69卷 / 2-3期

关键词：

D O I：

10.1016/0021-9150(88)90023-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Administration of the pineal hormone melatonin to genetically hypercholesterolemic rats resulted in a decrease in plasma cholesterol levels and in an improvement of fatty changes of the liver. Thus, the antihyperlipemic effect of melatonin, which was first discovered in hypercholesterolemia produced by short- or long-term administration of glucocorticoids, has now been proved to be rather universal and not simply anti-glucocorticoidal. The mechanism of the decrease of plasma cholesterol levels remains unknown. It was also found that the pathogenesis of this so-called genetic hypercholesterolemia in rats involved biochemical nephrotic changes and histopathological changes in the kidney.

引用

页码：269 / 272

页数：4

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