A NEW APPROACH TO THE SYNTHESIS OF 2-SUBSTITUTED INDOLES - REACTION OF DIMETALLATED ORTHO-TRIMETHYLSILYLMETHYLANILIDES WITH ESTERS

被引：18

作者：

BARTOLI, G ^{[1
]}

PALMIERI, G ^{[1
]}

PETRINI, M ^{[1
]}

BOSCO, M ^{[1
]}

DALPOZZO, R ^{[1
]}

机构：

[1] DIPARTIMENTO CHIM ORGAN,I-40136 BOLOGNA,ITALY

来源：

TETRAHEDRON | 1990年 / 46卷 / 04期

关键词：

D O I：

10.1016/S0040-4020(01)86701-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-trimethylsilylmethylanilides and esters in basic medium provides a new general method for the synthesis of indoles. The advantages of this method are the mild reaction conditions (-10-0°C), the ready availability of the starting materials and the use of a non-nucleophilic base (lithium 2,2,6,6-tetramethylpiperidide) to promote cyclisation. © 1990.

引用

页码：1379 / 1384

页数：6

共 15 条

[1]

[Anonymous], 1984, COMPREHENSIVE HETERO, DOI [10.1016/b978-008096519-2.00056-4, DOI 10.1016/B978-008096519-2.00056-4]

[2] REACTION OF PHENACYLTRIPHENYLARSONIUM BROMIDE WITH AROMATIC PRIMARY AMINES - SYNTHESIS OF 2-ARYLINDOLES AND 2-ARYLBENZINDOLES THROUGH ARSENIC YLIDE [J].