NEUROFIBRILLARY TANGLES IN DEMENTIA-PUGILISTICA ARE UBIQUITINATED

被引：57

作者：

DALE, GE

LEIGH, PN

LUTHERT, P

ANDERTON, BH

ROBERTS, GW

机构：

[1] ST MARYS HOSP, SCH MED, DEPT ANAT & CELL BIOL, PRAED ST, LONDON W2 1PG, ENGLAND

[2] ST GEORGE HOSP, SCH MED, DEPT IMMUNOL, LONDON, ENGLAND

[3] INST PSYCHIAT, COLL NEUROL, LONDON SE5 8AF, ENGLAND

[4] INST PSYCHIAT, DEPT NEUROPATHOL, LONDON SE5 8AF, ENGLAND

[5] INST PSYCHIAT, DEPT NEUROSCI, LONDON SE5 8AF, ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 02期

关键词：

D O I：

10.1136/jnnp.54.2.116

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ubiquitin, a protein thought to be involved in the ATP-dependent nonlysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.

引用

页码：116 / 118

页数：3

共 20 条

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