A NEW TOPOISOMERASE-II INHIBITOR, BE-10988, PRODUCED BY A STREPTOMYCETE .1. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

被引：38

作者：

OKA, H

YOSHINARI, T

MURAI, T

KAWAMURA, K

SATOH, F

FUNAISHI, K

OKURA, A

SUDA, H

OKANISHI, M

SHIZURI, Y

机构：

[1] BANYU PHARMACEUT CO LTD,EXPLORATORY RES LABS,2-9-3 SHIMO MEGURO,MEGURO KU,TOKYO 153,JAPAN

[2] BANYU PHARMACEUT CO LTD,OKAZAKI RES LABS,OKAZAKI 444,JAPAN

[3] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 05期

关键词：

D O I：

10.7164/antibiotics.44.486

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new topoisomerase inhibitor, BE-10988, was isolated from the culture broth of a strain of actinomycetes. The producing strain had a close resemblance to Streptomyces fimicarius and Streptomyces xanthocidicus. The active principle was extracted from the whole broth of strain BA10988 with ethyl acetate and purified by silica gel chromatography and by HPLC. BE-10988 increased DNA-topoisomerase complex formation and inhibited the growth of both doxorubicin-resistant and vincristine-resistant P388 murine leukemia cell lines, as well as sensitive P388 cell lines.

引用

页码：486 / 491

页数：6

共 15 条

[1]

HSIANG YH, 1985, J BIOL CHEM, V260, P4873

[2]

LOCK RB, 1987, ANTI-CANCER DRUG DES, V2, P151

[3] EFFECT OF GENISTEIN ON TOPOISOMERASE ACTIVITY AND ON THE GROWTH OF [VAL-12]HA-RAS-TRANSFORMED NIH-3T3 CELLS [J].